To level physical, son obvious the differences between a man and woman; Likewise, science has also shown that ways of thinking also vary according to gender – although the organization of the brain is very similar between the two.
Now, new research carried out by Moran Gershoni and his collaborators from the Department of Molecular Genetics at the Weizmann Institute of Science -Israel- and published in BMC Biology has also shown that the genetic expression of men and women is highly variable According to the tissue studied, something that would corroborate why men tend to suffer more body hair growth, or why women tend to accumulate more fat, among other findings.
Genetics by gender
The study evaluated the genes of up to 53 different tissues of the human body, such as the heart, foot, muscles, fat and reproductive organs of 550 people. In these tissues, the gene expression thereof; that is, if each gene was “activated” or “turned off” to a greater or lesser extent.
It is important to be clear about the concept, since the genetics of men and women is not different, but their expression.
According to this work, up to 6,500 out of 20,000 differently expressed human genes as studied in a man or a woman in at least one type of tissue
For example, it was found that some genes related to body hair growth they were expressed more in the skin cells of men compared to women. Also, genes for muscle growth they were expressed more in the muscle cells of men compared to women.
On the other hand, fat storage genes they were expressed more in the fat cells – adipocytes – of women compared to men. Also, genes for certain liver enzymes they are expressed more in women; One of the functions of these enzymes is to help the liver to detoxify substances, something that would be logical, since various studies have shown that men and women have a different response to drugs.
Finally some mammary gland genes they were expressed much more in one of both sexes: in men. Although it sounds paradoxical, the researchers say that it does make sense, since the function of these genes could be suppress lactation.
The genetics of diseases according to gender
The scientists suggest that some of their findings could shed light on the mechanism of some diseases currently under study. For example, him gen NPPB it was expressed much more in younger women, but its expression decreased with age. This gene has been related to risk of heart disease after menopause, which would indicate that its high expression would be a protective factor.
On the other hand, there was a gen which was expressed much more in the women’s brains than in men; the function of this gene is unknown, but it is speculated that it has some kind of role in the protection of women in front of Parkinson’s disease.
Finally, this research may also have shed light on the causes of infertility: there were genes that showed a “gender bias”, that is, they were genes that were more expressed in one of the two genera and precisely those genes tended to accumulate more persistent mutations after several generations. Among these genes, those responsible for infertility stood out, both in men and women.